Two-way sensitivity analysis

Two-way sensitivity analysis is a technique used in economic evaluation to assess the robustness of the overall result (typically of a model-based analysis) when simultaneously varying the values of two key input variables (parameters).This is particularly useful when there is a correlation between the two variables that are tested, in which case varying them independently in univariate sensitivity analyses may give a misleading view. Examples of such correlated input parameters might be hazard ratios for progression-free survival and overall survival for cancer therapy, or utility values for moderate and severe disease states.