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Peer-reviewed publication

Reported Demographics of Primary Immunodeficiency Diseases in the United States

YHEC authors: Lavinia Ferrante di Ruffano, Emma Carr, Mary Edwards, Mick Arber

Publication date: October 2025

Journal: The Journal of Allergy and Clinical Immunology: In Practice

Abstract

BACKGROUND: Primary immunodeficiency diseases (PIDDs) are rare genetic disorders impairing immunity. Studies evaluating diagnostic rates of PIDDs in historically marginalized US populations are limited. OBJECTIVE: To conduct a scoping review...

Peer-reviewed publication

The Cost-Effectiveness of Opicapone Versus Entacapone as Adjuvant Therapy for Levodopa-Treated Individuals With Parkinson’s Disease Experiencing End-of-Dose Motor Fluctuations

YHEC authors: William Green, Jamie Bainbridge

Publication date: September 2025

Journal: Parkinson's Disease

Abstract

BACKGROUND: In levodopa-treated individuals with Parkinson’s disease (PD) and end-of-dose motor fluctuations, the BIPARK-I randomized controlled trial (RCT) demonstrated that opicapone is noninferior to entacapone in reducing OFF-time. Furthermore, the...

Conference proceeding

Investigating Input Correlation in Probabilistic Sensitivity Analysis

YHEC authors: Erin Barker

Publication date: September 2025

Conference: Royal Statistical Society Conference

Type of conference proceeding: Podium

Abstract

OBJECTIVES: Probabilistic sensitivity analysis (PSA) is used to characterise uncertainty in cost-effectiveness models. A model was developed using R and Shiny to explore the impact of different parameter correlation structures...