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Our latest research, all in one place. Browse our collection of journal articles, reports and conference proceedings to see how we’re contributing to HEOR research. Remember to: 

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Peer-reviewed publication

The Initial Evaluation of the Scottish Telecare Development Programme

YHEC authors: Sophie Beale, Paul Truman, Diana Sanderson, Jen Kruger
Publication date: April 2010
Journal: Journal of Technology in Human Services

Abstract

In 2006 the Scottish Government provided just over £8 million to help 32 health and social care partnerships to develop telecare services. This paper presents a summary of the 2007-2008 evaluation of the Scottish Telecare Development. This evaluation focused on measuring overall program progress toward eight predefined Scottish Telecare Development objectives. Results indicate that the initial investment has resulted in significant savings to the health and social care sectors. Additionally, telecare provides opportunities to promote independence and improve the quality of life of service users and their informal carers. However, some caution needs to be taken in interpreting the findings as results are based on self-reported performance from partnerships, and many of the reported monetary "savings" are actually efficiency savings and are unlikely, in practice, to be cash-releasing.

Peer-reviewed publication

Cost-Effectiveness of the Endeavour Stent in de novo Native Coronary Artery Lesions Updated with Contemporary Data

YHEC authors: John Hutton
Publication date: February 2010
Journal: EuroIntervention

Abstract

AIMS: The Endeavor zotarolimus-eluting coronary stent has been shown to reduce the restenosis rate compared to bare metal stents and has impacted other clinical measures such as mortality, acute myocardial infarctions (AMI) and target vessel revascularisation (TVR).

METHODS AND RESULTS: Using pooled efficacy data from the Endeavor clinical trial programme, a model was developed to compare the cost effectiveness of the Endeavor drug eluting stent (DES) with the Driver bare meal stent (BMS) over a four year time period. Endeavor was more costly but had an improved clinical outcome compared to Driver BMS over four years with a 4% reduction in deaths, 33% reduction in AMI and a 45% reduction in TVR. Late stent thrombosis was the only event showing an increased incidence for Endeavor of 0.2% compared to 0% for Driver. The incremental cost effectiveness ratio was £3,757/quality adjusted life years (QALY).

CONCLUSIONS: Although much controversy has surrounded the appropriate way to assess the cost effectiveness of DES technology, a comprehensive analysis is presented and this suggests that by using extended clinical trial data out to four years, the Endeavor DES in particular, but DES technologies in general, are cost-effective approaches to percutaneous coronary intervention.

Peer-reviewed publication

The Economics of Pressure Relieving Surfaces: an Illustrative Case Study of the Impact of High-Specification Surfaces on Hospital Finances

YHEC authors: Paul Trueman, Sarah Whitehead
Publication date: February 2010
Journal: International Wound Care

Abstract

Pressure ulcers are associated with a significant economic burden that, in many cases, is recognised as being avoidable. The effectiveness of pressure relieving surfaces is well documented and acknowledged in clinical guidelines on the prevention and management of pressure ulcers. Whilst pressure relieving surfaces are more expensive than traditional hospital mattresses, judicious use, targeted to patients most at risk, can help to reduce the incidence and costs of pressure ulcers in hospital settings. This review paper includes a summary of pivotal clinical evidence on pressure relieving surfaces as well as a suggested approach for modelling their financial impact on hospital budgets. Simple financial modelling suggests that pressure relieving surfaces could lead to financial savings for a hospital when used appropriately.

Peer-reviewed publication

UK Economic Evaluation and Vaccination Policy

YHEC authors: Matthew Taylor
Publication date: November 2009
Journal: Vaccines in Practice

Abstract

With the number of available health technologies increasing at a greater rate than ever before, there is a growing need to ensure that decision-makers have the necessary tools to select and implement only those technologies that offer the greatest benefits to society. This, combined with the limited budgets available to healthcare providers, means that rigorous assessment of the benefits and costs of new interventions is both useful and necessary.

Peer-reviewed publication

How Well Do Search Filters Perform in Identifying Economic Evaluations in MEDLINE and EMBASE

YHEC authors: Julie Glanville
Publication date: October 2009
Journal: International Journal of Technology Assessment in Health Care

Abstract

OBJECTIVES: Health technology assessment (HTA) agencies assessing the cost-effectiveness of healthcare technologies seek evidence from economic evaluations. As well as searching economic evaluation databases, researchers often search MEDLINE and EMBASE, using search filters whose current performance is unclear. We assessed the performance of search filters in identifying economic evaluations from MEDLINE and EMBASE.

METHODS: A gold standard of economic evaluations was compiled from National Health Service Economic Evaluation Database (NHS EED) records for 2000, 2003, and 2006. Corresponding records were retrieved in MEDLINE and EMBASE. Search filters were identified from the InterTASC Information Specialists' SubGroup Web site and from Canadian Agency for Drugs and Technologies in Health (CADTH) Information Services. The sensitivity and precision of search filters in retrieving gold standard records from MEDLINE and EMBASE were tested.

RESULTS: A total of 2,070 full economic evaluations were identified from NHS EED. Of these, 1,955 records were available in Ovid MEDLINE and 1,873 were available in Ovid EMBASE. Thirteen MEDLINE and eight EMBASE filters were identified. NHS Quality Improvement Scotland (full and brief filters), the NHS EED and Royle and Waugh filters achieved over 0.99 sensitivity in MEDLINE. NHS Quality Improvement Scotland, CADTH, Royle and Waugh, and NHS EED filters achieved greater than 0.99 sensitivity in EMBASE. Filters demonstrated low precision.

CONCLUSIONS: This research provided new performance data on search filters to identify economic evaluations in MEDLINE and EMBASE. It demonstrated that highly sensitive economic evaluation filters are available, but that precision is low, yielding perhaps 5 relevant records per 100 records scanned.

Peer-reviewed publication

The Feasibility of Harmonizing Health Technology Assessments Across Jurisdictions: a Case Study of Drug Eluting Stents

YHEC authors: Paul Trueman, Matthew Bending, John Hutton
Publication date: October 2009
Journal: International Journal of Technology Assessment in Health Care

Abstract

OBJECTIVES: There is considerable interest in the potential for harmonizing health technology assessments (HTA) across jurisdictions. This study aims to consider four HTAs of drug eluting stents to determine the degree to which the methods adopted, evidence considered, and resulting recommendations diverge.

METHODS: Four HTAs of drug eluting stents were selected for inclusion and evaluated using a framework developed to systematically capture information on the process adopted, the evidence considered and the recommendations of each HTA.

RESULTS AND CONCLUSIONS: The findings suggest that, although there is a common core data set considered by most of the agencies, differences in the approach to HTA, heterogeneity of studies, and the limited relevance of research findings to local practice meant that the core data set had only limited influence on the resulting recommendations. Of the HTA agencies considered in the analysis, many sought to generate additional primary research from local settings to help inform the development of recommendations that were relevant to local practice. This raises questions about the extent to which HTA methods can be harmonized across jurisdictions.

Report

Economic Analysis of Interventions for Smoking Cessation Aimed at Pregnant Women

YHEC authors: Matthew Taylor
Publication date: September 2009

Abstract

No abstract available.

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